Leishmania donovani: Thionins, plant antimicrobial peptides with leishmanicidal activity
نویسندگان
چکیده
منابع مشابه
Leishmania donovani: thionins, plant antimicrobial peptides with leishmanicidal activity.
The leishmanicidal activity of plant antibiotic peptides (PAPs) from the principal families, such wheat thionins, a barley lipid transfer protein and potato defensins and snakins were tested in vitro against Leishmania donovani. Only thionins and defensins were active against this human pathogen at a low micromolar range of concentrations. Thionins resulted as the most active peptides tested un...
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Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stiboglucona...
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متن کاملPlant antimicrobial peptides
Pathogens, like fungi, nematodes, virus and bacterial are responsible for several human and plant diseases. According FAO, around 20 to 40 percent of crops yields are lost, per year, due plant diseases and pest. Besides this, only USA spend 30 billion dollars a year with hospital infections, and the numbers are increasing as the infection are becoming more and more resistant to conventional ant...
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ژورنال
عنوان ژورنال: Experimental Parasitology
سال: 2009
ISSN: 0014-4894
DOI: 10.1016/j.exppara.2009.03.019